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Vitamin B1
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Vitamin B1 (Thiamine)

Integrated Medicine

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Vitamin B-1, otherwise known as thiamine, is necessary for most every cellular reaction in the body as a participant in an enzyme system known as thiamin pyrophosphate. It is vital to normal functioning of the nervous system and metabolism. It can be found in meat, whole grains, fish, and nuts.

How This Vitamin Works in Your Body:
Maintains health of mucous membranes
Keeps normal workings of nervous system, heart, and muscles
Helps treat herpes zoster and beriberi
Supports normal growth and development
Restores deficiencies caused by alcoholism, cirrhosis, overactive thyroid, infection, breastfeeding, absorption diseases, pregnancy, prolonged diarrhea, and burns
Reduction of depression, fatigue, and motion sickness
Potential improvement in appetite and mental alertness

The Following May Benefit from this Vitamin:
Alcohol or other substance abusers by accelerating metabolism
Those with poor nutritional dietary intake
Age greater than 55 years old
Women who are breastfeeding or pregnant
Recent surgery patients
Those with liver disease, overactive thyroid, or prolonged diarrhea

Where This Vitamin is Found:
Baked Potato
Beef kidney/liver
Brewer's yeast
Flour; rye and whole grain
Garbanzo beans (chickpeas), dried
Ham
Kidney beans, dried
Navy beans, dried
Orange juice
Oranges
Oysters
Peanuts
Peas
Raisins
Rice, brown and raw
Wheat germ
Whole-grain products

How to Use:
Available as:
Liquid: the best form due to its high bioavailability and fast absorption. Always choose liquid as your first choice when supplementing your diet.

Tablets: available

Recommended Daily Intakes
Men: 1.2 mg
Women: 1.1 mg
Pregnancy: 1.4 mg
Lactation: 1.5 mg

Cautions:
Consult your doctor if you have:
Liver or kidney disease.

Over 55:
Not overly necessary.

Pregnancy:
Keep doses within DRI.

Breastfeeding:
Keep doses within DRI.

Storage:
Out of direct light and away from children in a cool, dry place. Heat/moisture may change effectiveness.

Symptoms of Deficiency:
Symptoms include fatigue, depression, decreased mental functioning, muscle cramps, nausea, heart enlargement, and eventually beriberi. Alcoholics are at increased risk of a deficiency.

Overdose:
Signs of Overdose:
Hypersensitive reactions resembling anaphylactic shock
Drowsiness

Side Effects:
Reaction or effect: What to do:
Skin rash/itch Discontinue. Consult doctor immediately.
Swelling of face Discontinue. Consult doctor immediately.
Wheezing Obtain emergency treatment immediately.

Interactions:
Interacts with: Combined effect:
Antibiotics: Decreases thiamine levels
Muscle relaxes during surgery: Excessive muscle relaxation.
Oral contraceptives: Decreases thiamine levels
Werknickes encephalopathy treatment: Before taking glucose, take thiamine.

Acidophilus (Lactobacillus)
Blue-Green Algae (Spirulina, Spirulina Maxima) Spirulina Platensis
Calcium (Calcium citrate) Calcium Gluconate)
Choline
Chondroitin Sulfate
Coenzyme Q (CoQ, Ubiquinoe, Coenzyme Q10)
Conjugated Linoleic Acid (CLA)
Creatine
Dehydroepiandrosterone (DHEA)
Desiccated Liver (Dessicated Liver)
Gamma-Linolenic Acid (GLA) Evening Primrose Oil)
Ginkgo Biloba (Ginkgoaceae)
Ginseng (Asian, American, Korean, Chinese, Panax, Quinquefolius)
Inositol (Myoinositol)
Iron (Ferrous Sulfate)

 
Jojoba (Goatnut, Simmondsia Chinensis)
L-Carnitine
Lecithin (Phosphatidylcholine)
Magnesium
Melatonin
Omega 3 Fatty Acids
Para-Aminobenzoic Acid (PABA)
Potassium (Potassium Chloride, Trikates)
Pregnenolone
Royal Jelly
Vitamin B-1 (Thiamine)
Vitamin B-2 (Riboflavin)
Vitamin B-3 (Niacin)
Vitamin B-5 (Pantothenic Acid)

 
Vitamin B-6 (Pyridoxine, pyridoxal phosphate)
Vitamin B-9 (Folic Acid) Folate, Pteroyiglutamic Acid) Folacin)
Vitamin B-12 (Cyanocobalamin)
Vitamin C (Ascorbic Acid)
Vitamin D (cholecalciferol, sunshine vitamin)
Vitamin E (alpha-tocopherol)
Vitamin H (Biotin)
Vitamin K (Phytonadione)
Vitamin P (Bioflavonoids, Phytochemicals)

Thiamine Helps Hepatitis Patients

Giving the B vitamin thiamine (Vitamin B1) to patients with chronic hepatitis B infection improves signs of the disease, a small preliminary study has found. This could point the way to a cheap and nontoxic way of treating the infection.

Hepatitis B virus (HBV) is spread through contact with the blood or body fluids of an infected person. HBV infects the liver, and in severe cases can lead to cirrhosis, liver cancer and liver failure. HBV can be treated with antiviral drugs and interferon, but there is no cure.

A researcher decided to test thiamine for HBV after a very bright and aware patient observed that his aminotransferase levels rose and fell depending on whether he was taking the vitamin.

High levels of aminotransferase enzymes indicate more active infection of the liver.

Investigators conducted a trial in this patient and two others with HBV infection to investigate the relationship. All had either failed treatment with interferon or could not tolerate the drug.

While patients were on thiamine treatment, their aminotransferase levels fell from abnormally high to normal levels; these levels increased when thiamine was subsequently withdrawn. And in subsequent liver biopsies after thiamine treatment, HBV DNA was undetectable.

This is the first study to investigate thiamine for treating hepatitis B infection. There are several potential ways that the vitamin might fight the infection.

For example, thiamine binds to iron and thus reduces the iron load in the liver. Past studies have linked high iron levels in the liver to more severe HBV infection, as well as a worse response to interferon.

The American Journal of Gastroenterology March 2001; 96: 864-868

Soy Formula Kills Three Babies

The "Remedia" brand of soy-based baby formula appears to have caused or contributed to three infant deaths and illness among other babies.

The formula, which is sold as a Kosher feed and is thought to be popular among Orthodox Jewish communities in New York and other areas, did not contain enough vitamin B1, which is vital to brain development. A company representative said that tests have shown the formula contained at least 10 times less B1 than was advertised.

An investigation is still underway to determine for sure whether the absence of B1 was to blame for the deaths and illnesses. The product has been recalled in Israel and parents who have fed their babies the formula are urged to get them booster shots of the vitamin.

BBC News November 10, 2003

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This information is provided for general medical education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient's medical condition.
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Last Modified : 03/15/08 04:15 AM