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Magnesium (Mg)

Integrated Medicine

Treatments

Magnesium (Mg) is a trace mineral that is known to be required for several hundred different functions in the body.  A significant portion of the symptoms of many chronic disorders are identical to symptoms of magnesium deficiency. 

Magnesium is one of the most plentiful minerals in the soft tissue. It is found in high concentrations inside cells, namely those of the brain and heart. The average adult body contains around 20-28 g of magnesium with about 60 percent is present in the bones. The rest is in the muscle, soft tissue and body fluids.

How it Works in Your Body:

  • Assist bone growth
  • Aids function of nerves and muscles, including regulation of normal heart rhythm
  • Conducts nerve impulses
  • Works as a laxative in large doses
  • Acts as antacid in small doses
  • Strengthens tooth enamel
  • Produces and transfers energy in the body
  • Maintains healthy heart, bones, muscles and blood vessels
  • Important in protein and carbohydrate metabolism
  • Aids in the transport of substances across cell membranes
  • Essential for the manufacture of genetic material
  • Activates essential enzymes
  • Helps transport sodium and potassium across cell membranes
  • Influences calcium levels inside cells
  • May help weaken the effects of lead poisoning
  • May reduce kidney stones
  • May be taken to treat heart disease
  • Anyone without proper caloric or dietary intake or with increased nutritional requirements
  • Those who abuse alcohol or other substances
  • People with a chronic wasting illness
  • Anyone who has recently undergone surgery
  • Vomiting and diarrhea may increase necessity
  • With medical supervision, may supplement treatment of acute myocardial infarction, cardiac surgery, digitalis toxicity and congestive heart failure.

Where it is Found:

  • Almond
  • Herring
  • Avocados
  • Leafy, green vegetables
  • Bananas
  • Mackerel
  • Bluefish
  • Molasses
  • Carp
  • Nuts
  • Cod
  • Ocean perch
  • Collards, beet greens
  • Shrimp
  • Dairy products
  • Swordfish
  • Flounder
  • Wheat germ
  • Halibut
  • Whole wheat bread
  • Peanuts
  • Baked beans
  • Beet greens
  • Brown rice, cooked
  • Kidney beans, can
  • Cashew nuts
  • Spinach, boiled
  • Halibut, baked
  • Chick peas
  • Black eyed peas
  • Artichokes
  • Apricots, dried
  • Sweetcorn
  • Green peas
  • Raisins
  • Whole wheat spaghetti, cooked
  • Avocado
  • Oatmeal, cooked

How to Use:
Take tablets, capsules and extended release tablets with a full glass of liquid. Do not chew or crush. Take with meals or 1 to 1-1/2 hours after meals unless otherwise advised by your physician.
Liquids or powders should be taken with at least one full glass of liquid while drinking plenty of fluids throughout the day. Follow the instructions provided by the manufacturer.

Available as:
Tablets
Capsules
Extended-release
Liquid
Powder
A constituent of many multivitamin/mineral preparations
Injection (given by doctors or nurses)

Recommended Daily Intakes:
Suggested Intake: 350-500 mg
Men (under 30): 400 mg
Men (over 30): 420 mg
Women (under 30): 310 mg
Women (over 30): 320 mg
Pregnancy (14-18): 400 mg
Pregnancy (19-30): 350 mg
Pregnancy (over 30): 360 mg
Lactating (14-18): 360 mg
Lactating (19-30): 310 mg
Lactating (over 30): 320 mg
Children(1-6 yrs): 80-130 mg
Children (9-13 yrs): 240 mg
Children (14-18yrs): 360-410 mg

Cautions:
Do not take if you have:
Kidney failure
Heart block (unless you have a pacemaker)
Had an ileostomy

Consult your doctor if you have:
Chronic constipation, colitis, diarrhea
Symptoms of appendicitis
Stomach or intestinal bleeding

Over 55:
It is more likely that adverse reactions and side effects will be experienced

Pregnancy:
There is a risk to the fetus, therefore do not take.

Breastfeeding:
Do not take magnesium unless advised by your physician to do so.

Storage:
Keep in a cool and dry location and away from direct light, but do not freeze.
Keep safely away from children
Do not keep in bathroom medicine cabinet. Heat and dampness may alter the action of the mineral.

Safe dosage:
It is advised that you consult with your physician for the proper dose for your condition

Others:
Excess magnesium is retained due to chronic kidney disease
Adverse reactions, side effects and interactions with medicines, vitamins or minerals occur only rarely when you take too much magnesium for too long or if you have kidney disease.

Symptoms of Deficiency:
Following symptoms occur rarely:

  • Muscle contractions and tremors
  • Convulsions
  • Confusion, delirium, memory and concentration difficulties
  • Irritability
  • Nervousness
  • Skin problems
  • Hardening of soft tissues
  • high blood pressure (hypertension)
  • Arrhythmia
  • Personality changes
  • Anorexia
  • Weakness, tiredness
  • Vertigo
  • Involuntary eye movements
  • Unsteady gait
  • Irregular heartbeat
  • Palpitations
  • Low blood sugar

Symptoms of advanced deficiency:

  • Loss of hair
  • Swollen gums
  • Damage to the arteries resembling atherosclerosis

Overdose:
Signs and symptoms : What to do?
Severe nausea and vomiting, extremely low blood pressure, extreme muscle weakness, difficulty breathing, heartbeat irregularity, fluid retention, lethargy, flushing of the skin, renal failure : Discontinue use of mineral. Call physician immediately.

Accidental Overdose:
Dial emergency or call your closest Poison Control Center for immediate attention.

Lab tests for deficiency detection:
Serum magnesium

Effect on lab tests:
Inaccurate test for stomach-acid secretion
May increase or decrease serum-phosphate concentrations
May decrease serum and urine pH

Side Effects:
Signs and symptoms : What to do?
Abdominal pain : Discontinue use of mineral. Call physician immediately.
Appetite loss : Discontinue use of mineral. Call physician immediately.
Diarrhea : Discontinue use of mineral. Call physician immediately.
Irregular heartbeat : Seek emergency treatment
Mood changes or mental changes : Discontinue use of mineral. Call physician immediately.
Nausea : Discontinue use of mineral. Call physician immediately.
Tiredness or weakness : Discontinue use of mineral. Call physician immediately.
Urination discomfort : Discontinue use of mineral. Call physician immediately.
Vomiting : Discontinue use of mineral. Call physician immediately.

Interactions:
Interacts with : Combined effect
Antibiotics (some) : Decreases magnesium levels.
Cellulose sodium phosphate : Decreases magnesium effect. Take 1 or more hours apart.
Diuretics (some) : Decreases magnesium level.
Ketoconazole : Reduces absorption of ketoconazole. Take 2 hours apart.
Mecamylamine : May slow urinary excretion of mecamylamine. Avoid combination
Tetracycline : Decreases absorption of tetracycline.
Vitamin D : May raise magnesium level too high.
Calcium : Regulates blood vessel tone and contraction of muscles, including heart muscle

 

Acidophilus (Lactobacillus)
Blue-Green Algae (Spirulina, Spirulina Maxima) Spirulina Platensis
Calcium (Calcium citrate) Calcium Gluconate)
Choline
Chondroitin Sulfate
Coenzyme Q (CoQ, Ubiquinoe, Coenzyme Q10)
Conjugated Linoleic Acid (CLA)
Creatine
Dehydroepiandrosterone (DHEA)
Desiccated Liver (Dessicated Liver)
Gamma-Linolenic Acid (GLA) Evening Primrose Oil)
Ginkgo Biloba (Ginkgoaceae)
Ginseng (Asian, American, Korean, Chinese, Panax, Quinquefolius)
Inositol (Myoinositol)
Iron (Ferrous Sulfate)

 
Jojoba (Goatnut, Simmondsia Chinensis)
L-Carnitine
Lecithin (Phosphatidylcholine)
Magnesium
Melatonin
Omega 3 Fatty Acids
Para-Aminobenzoic Acid (PABA)
Potassium (Potassium Chloride, Trikates)
Pregnenolone
Royal Jelly
Vitamin B-1 (Thiamine)
Vitamin B-2 (Riboflavin)
Vitamin B-3 (Niacin)
Vitamin B-5 (Pantothenic Acid)

 
Vitamin B-6 (Pyridoxine, pyridoxal phosphate)
Vitamin B-9 (Folic Acid) Folate, Pteroyiglutamic Acid) Folacin)
Vitamin B-12 (Cyanocobalamin)
Vitamin C (Ascorbic Acid)
Vitamin D (cholecalciferol, sunshine vitamin)
Vitamin E (alpha-tocopherol)
Vitamin H (Biotin)
Vitamin K (Phytonadione)
Vitamin P (Bioflavonoids, Phytochemicals)

The Miracle of Magnesium

By Carolyn Dean, MD, ND

Magnesium deficiency triggers or causes the following 22 conditions; the introduction of magnesium, either by a high-magnesium diet, with green drinks, or magnesium supplements, can help alleviate these conditions:

1.      Anxiety and Panic attacks

2.      Asthma

3.      Blood clots

4.      Bowel disease

5.      Cystitis

6.      Depression

7.      Detoxification?

8.      Diabetes, Syndrome X,
and Metabolic Syndrome

9.   Fatigue

10.  Heart disease

11.  high blood pressure (hypertension)

12.  Hypoglycemia

13.  Insomnia

14.  Kidney Disease

15.  Liver Disease

16.  Migraine

17.  Musculoskeletal conditions

18.  Nerve problems

19.  Obstetrics and Gynecology--premenstrual syndrome, dysmenorrhea (cramping pain during menses), infertility, premature contractions, preeclampsia, and eclampsia in pregnancy, lessens the risk of Cerebral palsy and Sudden Infant Death Syndrome (SIDS)

20.  Osteoporosis

21.  Raynaud's Syndrome

22.  Tooth decay

Science and medicine have both turned their backs on magnesium. Science opts out because the scientific methodology is defined by being able to test one thing at a time ending up with one result. Science finds magnesium too difficult to corral, partly because it is responsible for the correct metabolic function of over 350 enzymes in the body. The creation of ATP (adenosine triphospate) the energy molecules of the body, the action of the heart muscle, the proper formation of bones and teeth, relaxation of blood vessels, and the promotion of proper bowel function are all under the guidance of magnesium.

Why Don't We Hear More About Magnesium?

Medicine has turned its back on magnesium because most of the funding for medical research now comes from drug companies. Magnesium is not a patented drug and therefore will not be studied by drug companies, except to try to disprove its action.

While researching the book, "The Miracle of Magnesium," I found that doctors have been prescribing magnesium for heart disease since the 1930s. A review of seven major clinical studies showed that IV magnesium reduced the odds of death by more than half in patients suffering acute myocardial infarction (heart attack). One study, LIMIT-2, developed a protocol for giving magnesium as soon as possible after onset of the heart attack and before any other drugs. If those criteria were followed, heart muscle damage was greatly reduced, and neither hypertension nor arrhythmia developed.

Magnesium and the Heart

During and after a heart attack, people can suffer the following:

  • Extension of the area of heart damage as calcium floods into the muscle
  • Blood clotting, which blocks blood vessels in the heart muscle
  • Decreased blood flow as blood vessels go into spasm
  • Arrhythmia as the areas where muscle contraction in the heart originate are damaged

 

Magnesium is able to:

  • Dilate blood vessels
  • Prevent spasm in the heart muscle and blood vessel walls
  • Counteract the action of calcium, which increases spasm
  • Help dissolve blood clots
  • Dramatically lessen the site of injury and prevent arrhythmia
  • Act as an antioxidant against the free radicals forming at the site of injury 1-4

One of the main reasons that heart drug digoxin becomes toxic is because there is not enough magnesium in the body. 5

A drug trial called ISIS sought to disprove the effects of magnesium. In the ISIS trial the protocol was not followed in that magnesium was not the first drug given, and often it was not given for many hours or days after a heart attack was well established, causing widespread damage and blood clotting. Yet, drug reps can dutifully tell their doctor clients that ISIS proved that magnesium is worthless for heart disease! 6 Since the LIMIT-2 and ISIS trials, another smaller trial with only 200 people who were given IV magnesium at the onset of a heart attack, experienced a 74 percent lower death rate. 7

In spite of the fact that heart drugs, mainly diuretics, have the bad habit of depleting magnesium--along with potassium and even though magnesium is absolutely required for stabilizing heart muscle activity--magnesium is not utilized properly by conventional medicine.

Magnesium's Role in a Healthy Body

A small group of international magnesium researchers, however, have continued, against all odds, to prove the importance of magnesium not only as a nutrient for thousands of body processes but also as a medicine to treat magnesium-depleted health conditions. Drs. Bella and Burton Altura are two hard-working magnesium heroes! They have performed laboratory research and clinical research to the tune of about 1,000 studies over the past 40 years. The Alturas personally confirmed that the 22 magnesium-related conditions, listed at the beginning of this article, have a solid basis in science.

Dr. Burton Altura said that during his 40 years of research he was appalled at the lack of attention given to this life-saving nutrient. He has all but given up on conventional medicine recognizing the need for magnesium in its protocols for dozens of diseases and welcomed books such as mine to help spread the word. Without million-dollar marketing budgets that drug companies have for their latest drugs, nutrient research plods along--proving over and over again their worth but never being able to get that information out to the public.

Up to 80 Percent of Americans are Magnesium-Deficient

Another reason that Dr. Altura felt magnesium was not given its due is because there has been no lab test that will give an accurate reading of the magnesium status in the tissues. Only one percent of magnesium of the body is distributed in the blood, making a simple sample of magnesium in the blood highly inaccurate. That's why most doctors who rely on blood tests for magnesium and not magnesium deficiency signs and symptoms and realization that up to 80 percent of the population is deficient, will miss an important diagnosis.

There's even more to the actual way magnesium works. It exists in the body either as active magnesium ions or as inactive magnesium complexes bound to proteins or other substances. A magnesium ion is a group of atoms that is missing an electron, which makes it excitable as it searches to attach to something that will replace its missing electron.

Magnesium ions constitute the most physiologically active fraction of magnesium in the body; they are free to join in biochemical body processes and are not attached to other substances. 8 Most clinical laboratories only assess total "serum" magnesium, which mixes up both active and inactive types.

The Alturas took it upon themselves to develop and research a method that would test specifically for magnesium ions. It came about in 1987 and is called the Blood Ionized Magnesium Test. Its accuracy has been confirmed countless times with sensitive digital imaging microscopy, atomic absorption spectroscopy and the magnesium fluorescent probe. With this test it is now possible to directly measure the levels of magnesium ions in whole blood, plasma and serum using ion-selective electrodes. 8 The Alturas have used the ionized magnesium test in hundreds of research trials on dozens of different conditions proving, for example, that the 22 conditions listed above are related to magnesium deficiency. 9-15

Unfortunately, I'm not able to tell you that the ionized magnesium test is readily available. The Alturas do ionized magnesium tests at their laboratory at SUNY in New York and the testing equipment is available through an outside manufacturer to interested labs. (I've included the Altura contact information, below.)

How to Get Enough Magnesium

How do I get enough magnesium is a question that I'm frequently asked. If there is enough magnesium in the soil where green leafy vegetables, nuts, and seeds are grown then we have a chance to obtain magnesium from our diet. Organic foods may have more magnesium, but only if farmers replenish their soil with magnesium-rich fertilizers. Most fertilizer used on factory farms relies heavily on nitrogen, phosphorous, and potassium to make plants grow and appear healthy.

However, if magnesium and other minerals and micronutrients are not introduced the plants may look good but are not packed with the nutrition we need. Growers should be required to use top-quality fertilizers and should test their crops for the long list of nutrients we need to stay healthy.

In general, to get as much magnesium as possible in the diet, eat plenty of organic leafy green vegetables, nuts and seeds every day. Adding green drinks to your menu will help you achieve a higher magnesium status. However, if you are suffering from the following symptoms you may need supplemental magnesium:

muscle twitches, tics, or spasms

"Charlie horse" (the muscle spasm that occurs when you stretch your legs)

Insomnia or restless sleep

stress

back pain

headaches, cluster Headache, migraines

stiff and aching muscles

bones and joints that need continued chiropractic treatment

weakness

hypoglycemia

Diabetes

nervousness

hyperactivity

High blood pressure

osteoporosis

PMS

constipation

angina

kidney stones

aging

Depression

heart attack

irregular heartbeat

attention deficit disorder

aggressive behavior

chronic fatigue syndrome

Stroke

Anxiety

confusion, muscle weakness

hiccups

 

high-strung

exhaustion from exercise

seizures

 

The Calcium-to-Magnesium Ratio

Supplementing with magnesium must also take into account the balance between calcium and magnesium. Finland, which, from 1973 to 1999 had the highest recorded incidence of heart attack in middle-aged men in the world, also has a high calcium-to-magnesium ratio in the diet at 4 parts calcium to 1 part magnesium. 16-17 Americans in general have a high calcium-to-magnesium ratio in their diet and consequently in their bodies; the U.S. ratio is 3.5-to-1. Our dietary emphasis on a high calcium intake without sufficient magnesium and because of the excessive emphasis on women taking high doses of calcium for osteoporosis, we are creating more imbalance between the two minerals.

Some researchers predict that the American ratio of calcium to magnesium is actually approaching 6-to-1, yet, the recommended dietary ratio of calcium to magnesium in the United States is 2-to-1. Current research on the paleolithic or caveman diet shows that the ratio of calcium to magnesium in the diet that our bodies evolved to eat is 1-to-1. 18 In order to offset the deficiency magnesium induced by excess calcium and to treat the above 22 conditions, people may find it necessary to ingest one part magnesium to one part calcium in supplement form for a period of months to a year. Stabilization on a healthy diet including green drinks may be possible after that time.

The most commons sources of magnesium are oxide, citrate, glycinate, and malate. People use oxide and citrate if they suffer from constipation to take advantage of magnesium's laxative effect. Glycinate seems to cause little diarrhea and is the best choice for people who already have loose stools. Magnesium malate has been promoted for people with Fibromyalgia to help break up lactic acid that seems to be part of the Fibromyalgia picture.

Dr. Carolyn Dean is a medical doctor and naturopathic doctor. She is a writer, researcher, and health advocate. She is the lead author on Death by Medicine and a health advisor to yeastconnection.com and curesnaturally.com. She has written several health books including "The Miracle of Magnesium". Her Web site is carolyndean.com. The Miracle of Magnesium is written for both the lay public and practitioners. It is packed with hundreds of journal references that will convince doctors of the importance of magnesium and its efficacy in dozens of conditions--before reaching for the prescription pad.

 

 

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