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Q1: Does anyone have any information on possible links for overdose of vitamin D and arterial calcification formation?

Also, any treatment recommendations for patients with severe coronary artery calcification?

thanks,
YunNam Hong, MD
THI

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Q2: I procured vit D3.
The available tablet in S. Africa is 50,000 i.u., equivalent to: 1.25 mg of calciferol.
The above article suggests a dose of 5,000 i.u..
Should this be stated as: 50,000 i.u.?
Assuming the dose is 1 X 50K i.u. tablet daily.
The accompanying flyer states that overuse could develop a hypercalcemia.
Does the taking of vitamin D3 depend also on one's biovailability and absorption of calcium; and the solar environment in which one lives...e.g., winter and summer conditions, light/dark area conditions?
As with all 'preferable' lifestyles, the regular ingestion too of filtered water, deep breathing exercises and brisk walking.
God Bless,
Ron Beare.

A1: IV chelation and IV Phosphatidyl Choline.

D. Hopper MD

A2: If you look at the 1,25 dihydroxy vitamin D, you could get the false impression that there's too much vitamin D, as it can go high when there is a vitamin D deficiency (as well as other conditions). 25 hydroxy vitamin D will get you the storage form of vitamin D and is the appropriate test. Vit D3 is better then D2 (which is synthetic, has a shorter half-life, and doesn't stimulate the vit D receptors quite so well, but can do in a pinch), and I'd be nervous about going over 5,000iu daily without a good reason. The 50,000iu tabs are more for weekly or monthly dosing. Vit D3's half life is about 2 weeks, so weekly dosing is certainly reasonable. Always a good idea to check levels before starting and after 6 half-lives (3 months).

Dr. Malcolm Sickels, MD
210 Little Lake Drive, Suite 10
Ann Arbor, MI 48103
http://drsickels.com

A3: Don't guess or assume about Vit D supplementation. I cycle a couple of hours/day in the West Texas sun and assumed I made plenty of Vit D.My test showed a deficiency 2 years ago. After taking 5000mg/day since then, my retest shows I'm at 32ng/ml,just barely above therapeutic.
Vitamin D is not a substitute for estrogen or any other hormone. The studies relating estrogen to Alzheimer's and other diseases associated with inflammation were done using Premarin, an animal estrogen cocktail that is toxic in humans. This is not the estrogen complex produced by humans. Human estrogens do mitigate osteoclastic activity as well as the activity of other cells in the macrophage lineage. All hormones, including Vitamin D, must be kept at optimum levels for optimum health. The therapeutic power of these human estrogens is reflected in the absence of heart disease and Alzheimer's in women prior to menopause.
Colon cancer, Alzheimer's and osteoporosis are all linked by the process of inflammation, underwritten by an activated immune system. Diabetes, vascular disease, auto-immune disease, acne, depression, GERD, hypertension, ED, obesity and a growing list of other diseases are all underwritten by the same process. The immune system becomes activated when micro-organism levels are too high. This happens with the hormonal decline that begins around age 27 and a high glycemic diet. Vitamin D has its role, but it is not a panacea, nothing is. It should be used as part of a comprehensive orthomolecular program.
Roby Mitchell M.D.(Dr Fitt)

A4: Curr Opin Lipidol. 2007 Feb;18(1):41-6. Links Vitamin D and vascular calcification.Zittermann A, Schleithoff SS, Koerfer R.
Department of Cardiothoracic Surgery, Northrhine Westfalia Heart Center, Ruhr University Bochum, Bad Oeynhausen, Germany.

PURPOSE OF REVIEW: Vascular calcification is frequently found in patients with osteoporosis, atherosclerosis and chronic kidney disease, leading to high morbidity and mortality rates. The effects of vitamin D excess and deficiency on vascular calcification are reviewed in this article.

RECENT FINDINGS: There is evidence from experimental studies that mediacalcinosis induced by vitamin D excess is an active and reversible process. Vitamin D excess, however, is rarely seen in the general human population. Experimental data also demonstrate that physiologic vitamin D actions include the inhibition of processes that are important for intimal and medial artery calcification such as pro-inflammatory cytokine release, adhesion molecule release, and proliferation and migration of vascular smooth muscle cells. In uremic rats, low levels of the vitamin D hormone calcitriol are associated with massive vascular and soft tissue calcifications. Whereas retrospective studies already indicate a beneficial effect of active vitamin D on mortality rates in chronic kidney disease, little is yet known about the effect of vitamin D deficiency on cardiovascular morbidity and mortality in the general population.

SUMMARY: Available data indicate that vitamin D exerts a biphasic 'dose response' curve on vascular calcification with deleterious consequences not only of vitamin D excess but also of vitamin D deficiency.

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I think, first of all, you should consult an experienced doctor to avoid the possible problems with wrong treatment. And if it does not help you, you can even apply to some scientists in this sphere. They constantly find new methods of such diseases treatment. For example, some months ago I read an article about modern means of arthritis treatment and I found it very useful for me.