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Q: I have noted that patients experience adverse reactions frequently when taking di-thiol compounds such as DMSA or DMPS manifesting exacerbations of their conditions after initial good responses. Their intolerance to the di-thiol compounds can be profound. If mercury and lead are the primary offenders that we are seeking to chelate, is there a role for high dose IVC in such patients? If so do we know the mechanism of action of Vit C? Which other agents would be helpful? Thank you.

Cesar A. Maurtua M.D.

A1: An alternative oral medication is d-penicillamine 250mg. Tabs 2 po qid on Monday and Thursday only gives good metal detox especially for lead and mercury as d-penicillamine is one chelator that passes the blood-brain barrier. If used in this pulsed fashion side effects are minimal and no long term side-effects accrue. It is suggested that the doses be given 1 hour before meals or 2 hours after meals as the biggest side effect is flatulence if taken with food. I have patients take this for 4 to 6 months and then recheck their toxicant metals and most tolerate it well and have good long term detox (although not as rapid as with IV detox). Bob Nash

A2: After having done many dozens of provocative tests and treatment series with DMSA and DMPS, I have seen only one or two adverse reactions. I wouldn't switch from them. I buy DMPS from Apothecure.
Maybe the source makes a difference???
Gordon Josephs, MD(H)
Scottsdale, AZ

A3: My former wife and I are best of friends. She came to visit from California a few years ago. She had seen a health practitioner, who asked her to have a DMPS provocative test for toxic metals. He was not licensed to administer it. I gave her the injection; she had a severe reaction; and was ill for about two weeks. That was the last time I gave intravenous DMPS to anyone. Previously, I had been treating a couple from the northwest coast of Florida with intravenous DMPS for mercury chelation. They each had several injections but no adverse reactions.

I recently sent a discussion of IVC in dental patients to the group that was published a couple of weeks ago. I included a letter by Ian Dettman, PhD about the value of IVC in an amalgam removal protocol. I suggest you check it out.

INFINITE LOVE, ROY B. KUPSINEL, MD/BLUE COSMIC EAGLE PO BOX 620550 OVIEDO, FL 32765-0550
http://www.kupmed.com http://www.skype.com ID: Rkupsinel

A4: I have seen similar problems with DMPS which is why i quit using it once Gary and David Quigg showed that mercury is chelated very effectively by EDTA, there really didn't seem to be much of a reason to use anything else (except maybe DMSA orally). Surprising to me is that many people still aren't aware of this but continue to look in the wrong place. the chelated mercury is found in the stool not in the urine. I believe the little bit we do see is stuff excreted through the bile from the liver and reabsorbed via the small intestines. this is the reason I never do EDTA IV without giving 3 grams orally. i don't believe we are doing our patients a service to chelate them only to have the heavy metals reabsorbed. When doing a stool test during a heavy metal challenge, i give 3 grams of CAEDTA push and 3 grams orally with a couple of charcoal tablets. in theory when the stool turns black, this is where the EDTA heavy metal complex is. this is where i have the patients obtain the sample. I have seen off the wall spikes of Hg with only EDTA when using this technique. Jeff Baird DO