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Q: I am seeing a 62 yo woman who has had a recent resection of an abdominal GIST tumor which is metastatic to lungs and liver.

She also has a h/o of TAH for pelvic leiomyosarcoma and is unable to tolerate Sutent or Gleevec. Has anyone had experience with this type of tumor or management of any other c-kit mutation related malignancies? If so, do you have any suggestions? Can anyone out there offer references or an explanation as to whether high dose IVC could somehow act as a TK inhibitor or help inhibit expression of c-kit (if, in fact, this is the cause)? Thank you, dear colleagues, for your input. Jennifer Sudarsky, MD FP