Information for integrative medicine, alternative doctor, naturopathic medicine, alternative health, holistic health, holistic healing

Q: 1) Is anyone aware of spinal pain and deformity in acne patients treated with Accutane, isotretinoin? If so, what have others found helpful to manage this? Has it been reversible?

Being that Vitamin A is associated with bone loss, isotretinoin, a molecular analogue of Vitamin A, may more potently interfere with Vitamin D metabolism.
2) Should people take Vitamin A supplements?

Bob

B. Robert Mozayeni, MD

A1: I am a dermatologist in Indiana and have had a lot of experience [unforturnately!] with Accutane. I used to prescribe it a lot, but I don't hardly ever prescribe it and ONLY if pushed against the wall by a patient who also has horrid disease because Accutane is bad news. To answer your question I would need to know what you mean by "deformity" and "spinal pain". Musculoskeletal pain is common in patients on Accutane and is found about 15% of the time. In basically all of those cases patients have a carnitine deficiency and studies have shown that carnitine supplementation of 3-6 grams a day will reverse musculoskeletal pain associated with Accutane. Now this wouldn't have anything to do with "deformity" of bones. Long term usage of Accutane can cause long tendon calcification and perhaps some bone resorption. But we are talking about 2 years of daily use in patients with rare skin disease. Is this "deformity" a documented osteopenia or is it paravertebral muscle spasm and pain?
As far as should we take Vitamin A...I do and I bet many on this forum do, but then I take a ton of supplements. Our foods are not reliable sources of OPTIMAL nutrition due to
1) Demineralization of our soils by irresponsible farming practices
2) Processing and food additives, fruits picked before they are ripe, etc....all the things that allow us to buy food conveniently at the local store.
3) Demineralization of all soils with minerals going into the ocean that occured during Noah's Flood...this explains Iodine deficiency well as well as other deficiencies.
4) Poor dietary habits
Thomas Eads, MD

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