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PostPosted: Fri Jun 27, 2008 2:28 pm 
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Location: Chiang Mai


Efficacy Comparison of Pueraria mirifica

Q: Maybe I am missing something but I don't see why P. mirifica would be better than kudzu (P. lobata) after reading through PubMed. There was one study comparing cultivated P mirifica to P. lobata, only concluding that there was lower diadzein and another that compared wild P. mirifica to P. lobata and showed lower antioxidant effect and significant correlation only with puerarin and a significant lack of correlation with daidzin, daidzein and genistein. Abstracts below.

So does anyone have experience with it? And has anyone tried the more available kudzu (ge gen/ P. lobata) successfully for menopausal symptoms? Maybe I'm missing something, but I don't see why P mirifica would be better than kudzu for the same uses based upon constituents (and P. mirifica seems to have consistency problems.) Don't know if these uses are traditional in Thailand but I haven't seen them used this way in China.

Karen S. Vaughan, L.Ac., MSTOM
Registered Herbalist (AHG)
253 Garfield Place
Brooklyn, NY 11215

Major isoflavonoid contents of the phytoestrogen rich-herb Pueraria mirifica in comparison with Pueraria lobata.
Cherdshewasart W, Subtang S, Dahlan W.
Department of Biology, Faculty of Science, Chulalongkorn University, Phyathai Road, Patumwan, Bangkok 10330, Thailand.

Pueraria mirifica tubers collected from 28 out of 76 provinces of Thailand and Pueraria lobata tubers collected from Guangzhou province, China were submitted to HPLC analysis with the established gradient system comprising 1.5% acetic acid and acetonitrile. Five major isoflavonoids, including puerarin, daidzin, genistin, daidzein and genistein, were adopted as authentic standards. P. mirifica tubers showed intra- as well as inter-provincial differences in isoflavonoid and total isoflavonoid contents. The difference in both cases should be mostly influenced by genetic and environmental factors. In comparison with P. lobata, P. mirifica population exhibited differences only with a lower amount of daidzein.
PMID: 16930918
..............................
Correlation of antioxidant activity and major isoflavonoid contents of the phytoestrogen-rich Pueraria mirifica and Pueraria lobata tubers.
Cherdshewasart W, Sutjit W.
Department of Biology, Faculty of Science, Chulalongkorn University, Phyathai Road, Patumwan, Bangkok 10330, Thailand.

The antioxidant activity of wild Pueraria mirifica collected from 28 of the 76 provinces of Thailand and Pueraria lobata collected from China were assessed by 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. P. mirifica tuberous extracts showed weak antioxidant activity in comparison with alpha-tocopherol. Six plant samples exhibited stronger antioxidant activity than the mean value of the P. mirifica population. In addition, the mean value of the P. mirifica population indicated significantly lower antioxidant activity than P. lobata. The analysis of the antioxidant activity of isoflavonoids revealed that puerarin and daidzein exhibited the same level of antioxidant activity as alpha-tocopherol. The results showed convincingly that puerarin and daidzein in the plant tubers may play an important role in antioxidant activity. The correlation analysis between antioxidant activity and major isoflavonoid contents of plant tubers indicated a significant correlation only with puerarin and a significant lack of correlation with daidzin, daidzein and genistein.
PMID: 17890070


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PostPosted: Fri Jun 27, 2008 2:30 pm 
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A: Dear Karen,

To start with the author GROWS Pueraria lobata and calls it Pueraria mirifica.
There are 13 species of Pueraria called Kwaaw Khrua in Thailand. In addition, Butea Superba, a male herb, of an entirely different species, is called Kwaaw Khrua, as is a black variety, of another completely different species.
The key difference between Pueraria lobata and Pueraria mirifica is miroestrol (a group). In 1952, scientists isolated a highly potent estrogen-like compound, PHYTOESTROGEN, from the herb that is unique to this plant only. The compounds that set Pueraria mirifica apart from any other phytoestrogen-containing plants in the Family Leguminosae are MIROESTROL and DEOXYMIROESTROL, which possess the highest estrogenic activity among the known phytoestrogens due to structural similarity to ESTRIOL, the main human estrogen. Pueraria mirifica also contains other chemicals--in addition to miroestrol and Deoyxmiroestrol--that belong to the ISOFLAVONE and COUMESTRAN groups of phytoestrogens, e.g., genistein, daidzein, daidzin, genistin and coumestrol that are usually found in soybeans. However, the estrogenic activity of miroestrol and Deoyxmiroestrol are about 3,000-times more potent than that of soy isoflavones. (Sayan Sawatsri, et al).
In addition, Pueraria mirifica has Phase I, Phase II and Phase III studies clearly demonstrating safety and efficacy. Not so, Pueraria lobata.
Miroestrol in Pueraria mirifica has been published in peer reviewed literature, since the 50’s. Only Pueraria mirifica has miroestrol (The Journal Nature Dec 3rd, 1960) We have a website http://www.puresterol.com with additional information.
Except for a significant difference in price, there would be no reasonable reason to use Pueraria lobata. If cost is the prevailing factor, over safety and efficacy, cost will be the deciding factor. There are simply no other benefits or similarities.

Dr. I. Sandford Schwartz (Dr. Sandy)
Bangkok Thailand

Attached is Miroestrol PDF from the Journal Nature, 1960

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