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PostPosted: Sat Jan 09, 2010 9:00 pm 
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Key to Hepatitis C May Be Two Cellular Proteins


(HealthDay News) -- Researchers have identified two cellular proteins that play an important role in hepatitis C infection, and they say the finding may point to new and less toxic treatments for the disease, which can lead to cirrhosis and liver cancer.

The conventional treatments for hepatitis C are interferon and ribavirin, which can cause major side effects and aren't effective in all patients. A new drug that targets cellular proteins rather than viral proteins would be an important advance in treatment, according to the team from the University of California at Los Angeles.

The researchers found that heat shock proteins 40 and 70 are major cellular factors in hepatitis C infection. They also discovered that a natural compound called Quercetin blocks the synthesis of these proteins and significantly inhibited viral infection in tissue culture.

Quercetin -- a plant-based bioflavonoid sometimes used as a nutritional supplement -- may have anti-inflammatory and antioxidant properties.

"This is an important finding because we can block these proteins with the idea of reducing the level of the virus in people and, ideally, completely eliminate it," study senior author Samuel French, an assistant professor of pathology, said in a UCLA news release.

The study was published in the December issue of the journal Hepatology.

A phase 1 clinical trial will be conducted at UCLA to determine if Quercetin is safe and effective in patients with type 1 hepatitis C. Only about 50 percent of patients with type 1 hepatitis C respond to treatment.

More information

The U.S. Centers for Disease Control and Prevention has more about hepatitis C.
http://www.cdc.gov/hepatitis/C/index.htm

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PostPosted: Thu Oct 23, 2014 3:20 pm 
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On the USA Network there is a drama series called, HOUSE, which is about a very specialized diagnostics unit at a major hospital. What is intriguing, is the fact that the technical aspects of the show are incredibly accurate and well done.

Anyway.... on an old episode, of course the patient was dying and no one knew why... not even Dr. Gregory House and his diagnostics team. Everything they tried - failed. They had done every type of "test" they knew how to do, and everything seemed "normal", yet the patient was rapidly getting "worse".

Then.. Dr. House (in total frustration) just blurts out, " Re-run the blood tests, and this time YOU do it - don't just use the computer!" Everyone grumbled, because they had already run every kind of test imaginable...in some instances, TWICE!

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