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PostPosted: Fri Mar 21, 2008 1:37 pm 
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Q: A patient recently diagnosed with ALS brought this article in for me to read regarding lithium carbonate delaying progression of ALS http://www.pnas.org/cgi/content/abstract/105/6/2052.
I performed a urinary toxic metals provocation test and he came back high in Lead so I have begun chelating with CaEDTA.
Given the last posting regarding uptake the role of lithium in the uptake of folate and b12 I am considering starting this patient on lithium Does anyone have any comments re pro's con's dosage on using the OROTATE form rather than carbonate?
Thanks,
Dr. Chris Spooner B.Sc. ND
Vernon BC Canada


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PostPosted: Tue Apr 01, 2008 10:10 pm 
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A1: The data only apply to Lithium Carbonate and the blood levels you are aiming for are 0.4 -0.8 Meq/l I believe; dosing at 75 mg BID and upping by 75 mg after rechecking blood level This study was originally destined for Parkinsons Dieseae, but was changed to ALS.(per Dr. Klinghardt) You may want to obtain his most recent seminar on Healing the Brain http://www.neuraltherapy.com jjadams md, mdh sedona az


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PostPosted: Tue Apr 01, 2008 10:11 pm 
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A2: Lithium Carbonate is what is sold as a medicine and people are, in my opinion, given way too much of it by doctors, like 1200 mg a day, at which dose it acts similar to your standard shut-up pill. It's a trace mineral, deficiency of which can have all kinds of nasty manifestations. Lithium Orotate, Lithium Arginate, or Lithium Aspartate are available in health food stores, and even they, at 50 mg or 100 mg doses, can cause overdose symptoms such as hair fall and confusion if continued too long. For those (few) clients I suggest it to, I suggest to take ONE pill at bedtime for 4 to 7 days or until they forget to take it, usually about 3 days. I coach them in recognizing the signs that they need it. It's been helpful for several "highstrung" clients, to even them out. I myself get squirrely about every 3-5 years and take it only one or two times.

Re: ALS, there is apparently some evidence that it is related either directly or indirectly to fungal issues in the body. Take a look at http://www.know-the-cause.com for more on this.

And of course, as in all work with physical wellness, a good nutritional program is a must, including Dr. Gordon's EDD.

Nancy Adams, LMT
Coos Bay


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PostPosted: Tue Apr 01, 2008 10:12 pm 
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A3: Given that lithium orotate does not have the narrow therapeutic window of lithium carbonate, is not thrown off by different water intake during chelation and can be taken by healthy people, used in the lithium-sodium-magnesium pump mechanism of the cells, I think that lithium orotate is safer for someone undergoing chelation. As well as for people not undergoing chelation. You may need to stabilize the patient on the lithium orotate first, as I know bipolar health professionals who originally didn't think it worked as well, but eventually found a therapeutic level, if bipolar is your concern.

Karen Vaughan, MSTOM
Licensed Acupuncturist, NCCAOM
Registered Herbalist (AHG)
253 Garfield Place
Brooklyn, NY 11215
http://www.byregion.net/profiles/ksvaughan2.html


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PostPosted: Tue Apr 01, 2008 10:13 pm 
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A4: I would imagine the orotate form would be better absorbed than the carbonate. I use lithium orotate based on Jonathan Wright's recommendation, and find it helps most people with neurologic disorders and anxiety/depression. Priority One makes a good product containing 5 mg lithium Dr Dan Carter Bozeman, MT

A5: I use the lithium orotate by http://www.vrp.com They have protocols for dose, I use one cap bid (4.8mg elemental) for patients w/ good results.If the client is using ro or distilled water will be low in Lithium unless supplementing.

Mary Couillard, PhD, ARNP
http://www.ginkgogarden.com


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PostPosted: Tue Apr 01, 2008 10:14 pm 
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A6: Make sure to do an aggressive Lyme work-up on this patient. I agree with heavy metal testing along with co-infection panel. Thanks Steve Meress MD Fox Valley Wellness Center


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PostPosted: Tue Apr 01, 2008 10:16 pm 
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A7: Forms of Lithium

Lithium Acetate consists of Lithium combined with Acetic Acid.
Lithium Aspartate consists of 2.564% Lithium combined with 97.436% Aspartic Acid.
Lithium Carbonate is a form of Lithium is used as a clinical drug by psychiatrists to treat Mania and Manic Depression. This form of Lithium is poorly absorbed at the cellular level. Consequently relatively large doses are required in order to exert therapeutic effects. It contains 20% elemental Lithium.

Lithium Chloride consists of Lithium bound to Chlorine.http://www.dreddyclinic.com/forum/viewtopic.php?f=11&t=33387
Lithium Citrate consists of Lithium bound to Citric Acid. This form of Lithium is poorly absorbed at the cellular level. Consequently relatively large doses are required in order to exert therapeutic effects.
Lithium Gluconate consists of Lithium bound to Gluconic Acid.

Lithium Orotate http://www.dreddyclinic.com/forum/viewtopic.php?f=21&t=33742 consists of 3.83% Lithium bound to 96.17% Orotic Acid. This form of Lithium is sold in low potency formats in health food stores in the USA. Lithium Orotate (despite the scarcity of its use by psychiatrists) is the optimal form of therapeutic/supplemental Lithium. The Orotic Acid component of Lithium Orotate facilitates the bioavailability of Lithium at the cellular level (i.e. it permits Lithium to enter the Mitochondria, Lysosomes and Glial Cells). The increased cellular bioavailability of Lithium Orotate results in significantly lower dosage requirements, which in turn results in significantly fewer side effects and little need for clinical monitoring of blood serum Lithium levels. It is claimed that Lithium Orotate is twenty times more bioavailable compared with prescription forms of Lithium. references

Purchasse Lithium Orotate - Natural Help for Mood Swings

Lithium Succinate consists of Lithium bound to Succinic Acid. This form of Lithium is sometimes prepared as an ointment and used in the treatment of Herpes Simplex and Genital Warts http://dreddyclinic.com/findinformation/ww/genitalwarts.php.

Lithium Sulfate consists of Lithium bound to Sulfur.

Dosage Recommendations
Need for Monitoring
There is a fine line between therapeutic and toxic levels of Lithium:
- Lithium should only be consumed under the supervision of a physician (due to its potentially toxic effects).
Lithium therapy requires that plasma levels of this mineral be monitored:
- Blood plasma levels should be held close to 0.7 mg per 100 ml as at this level there is no interference with Sodium and Potassium levels.
- If Blood Lithium concentration rises above 1.0 mg per 100 ml adverse effects will begin.

Average Human Body Content
The average human body contains a total of 2 - 3 mg of Lithium.

Therapeutic Dosage
The therapeutic dosage of Lithium (when administered under the guidance of a physician) ranges between 200 - 1,500 mg per day. Only people who are diagnosed as being Lithium deficient would be prescribed this dosage level.
The therapeutic dosage of Lithium for the treatment of Manic Depression is approximately 200 - 400 mg per day (however this dosage must be set by a physician). This corresponds to 1,000 - 2,000 mg per day of Lithium Carbonate.
Studies that have demonstrated the therapeutic effectiveness of low-dosage, natural Lithium derived from Vegetable sources have generally involved the use of 150 mcg per day.

Brain Enhancement Dosage
Some physicians recommend 1 x 20 mg of supplemental Lithium (in the form of Lithium Aspartate or Lithium Orotate) per day for the enhancement of Brain function in normal, healthy persons.

Bioavailability
Absorption
Lithium is absorbed into the human body very efficiently and completely It requires no specific absorption process. It is rapidly distributed throughout the body:
- 70% - 90% of ingested Lithium is absorbed via the Intestine.
- Blood Plasma levels of orally-administered Lithium peak within 30 minutes to three hours after its administration.
- The Blood Plasma half-life of Lithium is approximately 20 hours.
- Lithium crosses the Blood-Brain barrier slowly and incompletely - its concentration in Cerebrospinal Fluid reaches only 50% of that in Blood Plasma.

Excretion
50% of orally-administered Lithium is excreted by the Kidneys (unchanged) within 18-24 hours of ingestion, whilst the remaining 50% is excreted over the following 1-2 weeks.

Lithium - dosages (Research)

The following table lists the daily doses of Lithium recommended from a variety of sources/researchers:

Dosage Reference
1 mg Schrauzer, G. N. Lithium: occurrence, dietary intakes, nutritional essentiality. J Am Coll Nutr. 21(1):14-21, 2002.The available experimental evidence now appears to be sufficient to accept lithium as essential; a provisional RDA for a 70 kg adult of 1,000 microg/day is suggested.
7 mg Maintain your brain the Durk Pearson & Sandy Shaw way. Life Enhancement. May 2004.Experimental dosage used by the authors for brain enhancement purposes.
10 mg Wright, J. V. Lithium, part 1: protect and renew your brain. Townsend Letter for Doctors and Patients. February-March 2004.The author recommends 10 20 mg of lithium (from lithium aspartate or lithium orotate) per day for "brain anti-aging" purposes.
20 mg Wright, J. V. Lithium, part 1: protect and renew your brain. Townsend Letter for Doctors and Patients. February-March 2004.The author recommends 10 20 mg of lithium (from lithium aspartate or lithium orotate) per day for "brain anti-aging" purposes.

Also known as: Li
Brand Names: Camcolit; Eskalith; Lithicarb; Priadel

Description
Lithium is an alkali Metal recently recognized as essential in trace amounts in human nutrition. It is from the same chemical class of Minerals as Sodium and Potassium.

Health Benefits of Lithium
Cardiovascular System
Lithium may help to prevent Heart Attacks: [more info]
- Epidemiological studies have demonstrated that communities that have the highest levels of Lithium in their drinking water have the lowest incidence of Heart Attack.
Lithium may minimize the Brain damage that occurs subsequent to (ischemic) Stroke. references

Digestive System
Lithium may prevent Duodenal Ulcers: [more info]
- Epidemiological studies have demonstrated that communities that have the highest levels of Lithium in their drinking water have the lowest incidence of Duodenal Ulcers.
Lithium may prevent Gastric Ulcers: [more info]
- Epidemiological studies have demonstrated that communities that have the highest levels of Lithium in their drinking water have the lowest incidence of Gastric Ulcers.

Immune System
Lithium may help to prevent some types of Cancer. [more info] Lithium Succinate (ointment applied topically) may accelerate the healing of Herpes Simplex Viruses ( Herpes Simplex Virus Type 1 and Herpes Simplex Virus Type 2) lesions. Oral Lithium therapy may reduce the number of episodes of Herpes Simplex outbreaks, may reduce the duration of each episode and may reduce the severity of the symptoms of Herpes Simplex outbreaks. references Lithium may enhance the function of the Immune System. [more info] Lithium may stimulate the production of Lymphocytes. [more info] Lithium may stimulate Stem Cells. references Lithium may depress the Immune System's Suppressor T-Cells. [more info] Lithium may increase the production of White Blood Cells in persons with low White Blood Cell counts. references

Metabolism
Lithium may be useful for the treatment of Grave's Disease. references Lithium may be useful for the treatment of Hyperthyroidism. references Lithium concentrates in the Thyroid Gland.

Musculoskeletal System
Lithium concentrates in the Bones.
Lithium may be useful for the treatment of Fibromyalgia http://www.dreddyclinic.com/findinformation/ff/fibromyalgia.php. references Lithium may help to prevent and treat Gout: references
- Epidemiological studies have demonstrated that communities that have the highest levels of Lithium in their drinking water have the lowest incidence of Gout.
Lithium may prevent Rheumatism: [more info]
- Epidemiological studies have demonstrated that communities that have the highest levels of Lithium in their drinking water have the lowest incidence of Rheumatism.

Nervous System
Lithium may reduce Aggressiveness. references Lithium may inhibit the progression of Alzheimerโ€™s Disease (by protecting Neurons against Amyloid-Beta Protein-induced and Glycogen Synthase Kinase-3-inducd Cell death). references Lithium may be useful for the treatment of Anorexia Nervosa. references Lithium concentrates in the Brain (in the Pituitary gland).
Lithium sedates the Central Nervous System.
Lithium may treat and prevent some forms of Depression where the cause is difficulty in the transport of Sodium:
- Lithium (150 mg per day of the Lithium Orotate form of Lithium) alleviates (recurrent) Major Depression. references
- Lithium alleviates the Mania phase of Manic Depression. references Lithium may alleviate the Pain associated with (cluster) Headaches. references Lithium may prevent various Mental Ailments - especially Mood Disorders: [more info]
- Epidemiological studies have demonstrated that communities that have the highest levels of Lithium in their drinking water have the lowest incidence of suicides.
Lithium may alleviate the Pain associated with Migraines. references Lithium may help to maintain stable Moods and Emotions. references Lithium may facilitate the remyelinization of Myelin Sheaths. references Lithium may alleviate Neuralgia (due to its ability to stabilize Nerves). references Lithium may inhibit the ability of Amyloid-Beta Protein to destroy Neurons, Lithium stimulates the growth of Neurons and Lithium facilitates the regeneration of damaged Neurons. references Lithium may alleviate Obsessive-Compulsive Disorder. references Lithium may increase the duration of Slow-Wave Sleep (deep Sleep). references Lithium may improve Spatial Memory. references

Sexual System
Lithium concentrates in the Ovaries (and it has been speculated that Female Infertility may occur during Lithium deficiency). [more info]

Skin
Lithium (Lithium Succinate cream applied topically for four weeks) may alleviate Genital Warts. references Lithium may Enhance the Function of these Substances

Growth Factors
Lithium may increase the production of Brain-Derived Neurotrophic Factor (BDNF).
references

Hormones
Lithium may increase serum Parathyroid Hormone levels.

Neurotransmitters
Lithium may enhance the synthesis of Acetylcholine (possibly by increasing the uptake of Choline into Presynaptic Terminals of Neurons).
Lithium may stabilize the transmission of Serotonin through the Central Nervous System.
Lithium may increase blood plasma levels of Vasopressin.

Minerals
Lithium may enhance the transport of Sodium across Cell Membranes and may function in a similar capacity to Sodium when Sodium deficiency occurs.
Lithium may Counteract these Potentially Toxic Substances Amino Acids Lithium may inhibit the neurotoxic effects of Kainic Acid. references Enzymes Lithium may inhibit Glycogen Synthase Kinase-3. references Minerals Lithium may bind with and remove (chelate) Aluminium http://www.dreddyclinic.com/forum/viewtopic.php?f=34&t=32424 from the body. references Pharmaceutical Drugs The Lithium Carbonate form of Lithium may protect against the toxic effects of Chemotherapy on the Blood. [more info] Proteins Lithium may inhibit the ability of Amyloid-Beta Protein to destroy Neurons. references Recreational Drugs Lithium (Lithium Orotate form) may reduce the craving for Alcohol in Alcoholism patients. references

These Substances may Enhance the Function of Lithium

Amino Acids
Tryptophan (9,000 mg per day) may potentiate the beneficial effects of Lithium in the treatment of Manic Depression. [more info] Vitamins Inositol may counteract some of the potentially toxic effects associated with therapeutic doses of Lithium. references Vitamin E may enhance the function of Lithium. [more info] These Substances may Interfere with Lithium

Minerals
Sodium Bicarbonate http://www.dreddyclinic.com/forum/viewtopic.php?f=8&t=4505 may decrease serum Lithium levels (and persons prescribed Lithium as a Pharmaceutical Drug should therefore avoid supplemental Sodium Bicarbonate). references

Organic Acids
Tartaric Acid may decrease serum Lithium levels (and people prescribed Lithium as a Pharmaceutical Drug should therefore avoid supplemental Tartaric Acid). references Dietary Sources of Lithium references Small amounts of Lithium are present in almost all foods.

Dairy Products: Milk is one of the highest dietary sources of Lithium.
Eggs: Eggs are one of the highest dietary sources of Lithium.
Recreational Drugs: Tobacco Smoke contains Lithium (the effects of inhaled Lithium are unknown).
Sea Vegetables: Most Sea Vegetables contain small amounts of Lithium.
Vegetables: Sugar Cane
Water: Drinking Water contains approximately 0.002 mg of Lithium per liter.
Some Mineral Waters are comparatively high in Lithium.
Lithium may Interfere with these Substances Vitamins Excessive consumption of Lithium (especially Lithium Carbonate form) may cause Folic Acid deficiency.
Excessive consumption of Lithium (especially Lithium Carbonate form) may cause Inositol deficiency.
Lithium may cause the depletion of Vitamin B12. references

Toxic Effects of Excessive Lithium
The poor reputation of Lithium has arisen from psychiatrists prescribing Lithium in megadoses - it should always be borne in mind that extremely large dosages of Lithium can be FATAL - pay careful attention to the dosage recommendations listed below.

Digestive System
Blood Plasma Lithium levels above 1 mg per 100 ml may cause Diarrhea.
Blood Plasma Lithium levels above 1 mg per 100 ml may cause Nausea.
Blood Plasma Lithium levels above 1 mg per 100 ml may cause Vomiting.

Excretory System
Excessive Blood Plasma Lithium levels may cause Edema. references Excessive Blood Plasma Lithium levels may cause Frequent Urination.

Metabolism
Blood Plasma Lithium levels above 1 mg per 100 ml may cause Lethargy.
Musculoskeletal System
Blood Plasma Lithium levels above 1 mg per 100 ml may cause Muscular Tics (Tremors and Twitching).

Nervous System
Blood Plasma Lithium levels above 1 mg per 100 ml causes Speech Impairment.
Blood Plasma Lithium levels above 1.4 mg per 100 ml may cause Epilepsy.
Excessive Thirst may occur as a result of excessive consumption of Lithium.

Skin
Excessive Lithium levels may cause Acne.
Excessive Lithium levels may cause Psoriasis (and patients using high therapeutic dosages of pharmaceutical Lithium commonly experience Psoriasis). This occurs from Lithium depleting Inositol.


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PostPosted: Thu Jun 12, 2014 10:31 am 
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PostPosted: Tue Apr 28, 2015 11:02 am 
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Natural remedies for migraine headaches http://www.dreddyclinic.com/forum/viewtopic.php?f=35&t=28179&p=58082


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PostPosted: Thu Jun 01, 2017 9:27 pm 
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Excellent post. Thank you very much!!
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